Diabetes Complication and Pathophysiology
The physiology of insulin, pathophysiology of type II diabetes and its complications.
“Glucose metabolism is normally regulated by a feedback loop including islet β cells and insulin-sensitive tissues, in which tissue sensitivity to insulin affects magnitude of β-cell response. If insulin resistance is present, β cells maintain normal glucose tolerance by increasing insulin output. Only when β cells cannot release sufficient insulin in the presence of insulin resistance do glucose concentrations rise.” (Kahn, Cooper & Prato 2014).